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I got behind in opening my mailbox, so I'm sorry about the delay in responding
to your message.
While soluble CD8 antigen does exist, I'm not aware that it creates any
problem in quantifying lymphocytes that express the antigen on the cell
surface. As to your study of lymphocyte subpopulations in patients with
autoimmune disorders, I know that Dr. Colin Stephen Scott has investigated
both transient and persistent expansions of large granular lymphocytes in
association with the Yorkshire Leukaemia Group, and you might take a look at
their work:
Scott CS et al, Brit. J. Haematol., 1993, 83: 504-515.
Scott CS and Richards SJ, Blood Rev., 1992, 6: 220-233.
Good luck -- hope this is helpful.
***************************************************************
Christopher R. Conley, MD conley.christopher@mayo.edu
Dept. of Pathology Tel:(602)301-8021 FAX:(602)301-8372
Mayo Clinic Scottsdale 13400 E. Shea Blvd. Scottsdale AZ 85259
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