Re: ? Autofluorescent Haemoglobin

James Weaver 301-594-5879 FAX 301-594-3037 (WEAVER@cder.fda.gov)
Tue, 04 Jun 1996 13:33:52 -0400 (EDT)

I cannot speak to the specific type of hemoglobinopathy however,
porphyrin rings lacking the Fe atom have detectable fluorescence
with 488 excitation. If the patient was also iron deficient, this
might explain the additional fluorescence observed. Hope this helps
with your problem.

-Jim Weaver

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James L. Weaver Email: WEAVER@CDER.FDA.GOV
Molecular Pharmacology Phone: 301-594-5879
Division of Research & Testing FAX: 301-594-3037
OTR, CDER, Food & Drug Admin.
Laurel, MD
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