Big Lymphocytes

Jose C. Segovia (segovia@CIEMAT.ES)
Wed, 05 Jun 1996 10:48:15 +0000 (GMT)

Hello everybody,

I have a question to anyone who knows about thymic lymphomas.

We are analyzing some transgenic mice that develop a thymus 10 to 20 times
bigger than the non-transgenic littermate. The transgen is supossed to be
expressed only in epithelial cells. But, when we analyzed the enormous
thymus we found that the 95% of cells were CD4+ and Thy-1* (we expect a
clear increase in thymic epithelial-like cells). Moreover, those T cells
were bigger and more complex (about 5-10 times in a linear FS vs SSC
dot-plot). Thus, my question is:

Does anybody know if this increase in size and complexity is a parameter of
any thymic disease?

Thank you and sorry if this is a very basic question. I am a beginner in
these T cell problems.

Thanks again

Jose C. Segovia
Jose C. Segovia
Dpt. of Molecular and Cellular Biology
CIEMAT
Av. Complutense, 22
28040 Madrid
SPAIN

Tfn : 34 1 346 6484
Fax : 34 1 346 6393
E-mail : Segovia@ciemat.es

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